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Webinar at a glance:
Development of Stable Triarylmethyl Radicals for Biomedical EPR Applications
Moderated by: Viresh Rawal Ph.D., University of Chicago
About the Speaker: Dr. Benoit Driesschaert is an Organic Chemist, Assistant Professor at West Virginia University in the Department of Pharmaceutical Sciences. His laboratory develops stable triarylmethyl radicals used as spin probes and spin labels for biomedical EPR applications.
About the Webinar: Low-field electron paramagnetic resonance (EPR) with a molecular spin probe is a powerful technique to profile various biomarkers of the tissue microenvironment in vivo. This presentation will discuss the design, synthesis, and applications of triarylmethyl (TAM) radicals sensitive to important physiological parameters such as dissolved oxygen concentration, pH, inorganic phosphate (Pi) concentration, microviscosity, and enzyme activity.
Webinar at a glance:
EPR Imaging Outside the Pre-Clinic
Moderated By: TBD
About the Speaker: Dr. Biller is a Principal Chemist at TDA Research, Inc. in Golden, CO. He graduated from the Eaton Laboratory at the University of Denver in 2014, and was awarded the Bruker Biospin/Royal Society of Chemistry International Thesis award in 2015. After graduation Dr. Biller went to work with the Magnetic Imaging Group at NIST-Boulder, first as a National Research Council Post-doctoral scholar, and then as a Research Chemist. In 2018 he joined TDA Research, and has driven development of novel non-destructive evaluation techniques based in the interaction of electromagnetic waves with materials including carbon fiber and lithium-ion batteries. Dr. Biller has a deep interest in widening the application sphere of magnetometry, electron paramagnetic resonance and nuclear magnetic resonance methods outside of the laboratory environment. He is currently leading a NCI SBIR Phase I project to develop an in-vivo EPR imaging agent for clinical use.
About the Webinar: EPR Imaging is a powerful technique in pre-clinical small animal applications. Through EPRI, a spatial map of oxygen concentration can be created and used to guide targeted increased doses of radiation at hypoxic sites. This has been shown to improve the survivability in a mouse model. The transition of this very useful new tool into the clinic has not been straightforward. Concerns about toxicity of the imaging agents, a lack of familiarity with the EPR imaging hardware required, and the way in which the EPRI agent would be administered are all hurdles. This presentation will touch on development of a novel EPRI imaging agent where the paramagnetic probe has been attached to a nanoparticle and encapsulated with an oxygen permeable membrane. This separates the body and imaging agent environment, while still allowing O2 to access the paramagnetic site. This work, led by TDA Research Inc., has been supported by collaborations with West Virginia University, The University of Denver and O2M Technologies under a SBIR Phase I administered by the National Cancer Institute (NCI Contract #75N91020C00032).