Webinar at a glance:
EPR Imaging Outside the Pre-Clinic
Moderated By: Dr. Howard Halpern, University of Chicago
About the Speaker: Dr. Biller is a Principal Chemist at TDA Research, Inc. in Golden, CO. He graduated from the Eaton Laboratory at the University of Denver in 2014, and was awarded the Bruker Biospin/Royal Society of Chemistry International Thesis award in 2015. After graduation Dr. Biller went to work with the Magnetic Imaging Group at NIST-Boulder, first as a National Research Council Post-doctoral scholar, and then as a Research Chemist. In 2018 he joined TDA Research, and has driven development of novel non-destructive evaluation techniques based in the interaction of electromagnetic waves with materials including carbon fiber and lithium-ion batteries. Dr. Biller has a deep interest in widening the application sphere of magnetometry, electron paramagnetic resonance and nuclear magnetic resonance methods outside of the laboratory environment. He is currently leading a NCI SBIR Phase I project to develop an in-vivo EPR imaging agent for clinical use.
About the Webinar: EPR Imaging is a powerful technique in pre-clinical small animal applications. Through EPRI, a spatial map of oxygen concentration can be created and used to guide targeted increased doses of radiation at hypoxic sites. This has been shown to improve the survivability in a mouse model. The transition of this very useful new tool into the clinic has not been straightforward. Concerns about toxicity of the imaging agents, a lack of familiarity with the EPR imaging hardware required, and the way in which the EPRI agent would be administered are all hurdles. This presentation will touch on development of a novel EPRI imaging agent where the paramagnetic probe has been attached to a nanoparticle and encapsulated with an oxygen permeable membrane. This separates the body and imaging agent environment, while still allowing O2 to access the paramagnetic site. This work, led by TDA Research Inc., has been supported by collaborations with West Virginia University, The University of Denver and O2M Technologies under a SBIR Phase I administered by the National Cancer Institute (NCI Contract #75N91020C00032).
Webinar at a glance:
Rapid Scan EPR of Nitroxide Probes of Redox
Moderated by: TBA
About the Speaker: Gareth R. Eaton received his A.B. at Harvard and obtained his Ph.D. at MIT 1972. Since then he has been in the Department of Chemistry (now the Department of Chemistry and Biochemistry) at the University of Denver. He was promoted to Professor in 1980. He served as Dean of Natural Sciences from 1984-1988 and as Vice Provost for Research from 1988-1989. In 1997 he received the John Evans Professorship at the University of Denver. He teaches inorganic chemistry. His research program involves continuous wave, rapid-scan, and pulse EPR applied to the study of relaxation times, spin-spin interaction, metal ions in biological systems, and EPR imaging. He and his wife, Professor Sandra S. Eaton, have jointly authored over 400 research papers and book chapters. In 2002 they jointly received the Bruker prize and in 2008 they became Fellows of the International EPR/ESR Society. He is a Fellow of the Royal Society of Chemistry.
About the Webinar: A brief introduction to the relative benefits of CW, rapid scan, and pulsed EPR for solving various problems will be presented. Emphasis will be on applications to nitroxide probes designed to measure redox status of tissues.